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Seagen
Research Associate II Automated Conjugation
Research - Bothell, Washington
Description
Summary:
We are seeking a highly capable Biochemist or Chemist to perform high-throughput conjugation and characterization of antibody-drug conjugates (ADCs) as part of the core conjugation group within Research. This person will play a critical role in helping to develop and implement an automated conjugation process to evaluate new antibodies and ADC payloads.
Principal Responsibilities:
- Operation of Hamilton and/or Tecan automated liquid handlers
- High-throughput conjugation for screening antibodies and small molecule compounds
- Design and optimization of HTP conjugation and characterization methods
- Preparation, purification and characterization of ADCs using established and experimental conjugation methodologies
- Analytical characterization of antibodies and ADCs including HPLC, LC/MS and spectroscopy
- Collaborate on project teams, present data and demonstrate strong communication skills
- Data and report generation including regular review of data with manager, project leads and other research associates
- Preparation of critical reagents and maintenance of inventories
- Routine laboratory cleaning and equipment maintenance
Qualifications:
- Minimum of 2 years of post-baccalaureate lab experience in an academic and/or industry environment
- Minimum of 1 year experience operating automated liquid handlers such Hamilton or Tecan systems
- Experience programming and troubleshooting automated liquid handlers
- Experience in protein purification and liquid chromatography techniques
- Practical knowledge of chromatography, and UV spectroscopy. Analytical Mass Spectrometry experience desired but not required
- An ideal candidate will have previous experience performing bio-conjugation techniques
- Detail-oriented with strong analytical, organizational and multi-tasking skills
- Ability to perform routine tasks independently and commitment to high quality analysis and documentation
- Willingness to work with cytotoxic compounds, following safety protocols
- Knowledge of protein stability and formulation
- Prior experience working with electronic lab notebooks and/or LIMS systems is desired
- Team player with a track record of strong collaboration
Education:
- Bachelor’s or Master’s degree in chemistry, biochemistry or related field
As the leading employer in our industry in the Pacific Northwest, Seattle Genetics is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seattle Genetics, please visit www.seattlegenetics.com.
Seattle Genetics is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.
Apply:
Seagen
Seagen is an Equal Opportunity Employer
Submitted: 09/25/2020
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