Seagen

Principal Scientist Bioanalytical

Development - Bothell, United States

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Summary

The Translational Sciences department is seeking a highly motivated and creative principal scientist/AD to be a leader of a non-GLP bioanalytical team. This work will support the advancement of multiple antibody-drug conjugate (ADC) and immuno-oncology biotherapeutics from late-stage research into clinical development. The successful candidate will have experience in standard and exploratory bioanalytical techniques that can be used to characterize the pharmacokinetics, pharmacology, biodistribution, and/or stability of antibody-based drugs. This position also encompasses oversee of reagent identification through hybridoma campaigns and soluble antigen analysis. Position title will be commensurate with experience.

Principal Responsibilities:

• Oversee a group that Designs and develop ligand binding assays, immunopurification techniques, and novel bioanalytical methods used to measure and characterize therapeutic drugs or novel drug-linker platforms in various biological matrices.
• Lead a team responsible for research phase bioanalysis, and assay development.
• Serve as a representative of bioanalysis on program teams.
• Oversees the creation of critical reagents and their handoff to the GLP group.
• Analyze, summarize, and present data in group meetings and contribute to discussions and strategy in bioanalysis.
• Troubleshoot or analyze key questions pertinent to new programs

Required Qualifications:

• PhD in Biological Sciences or related discipline with a minimum 4 years experience. Alternatively, 5 year (+MS) of relevant research/industry experience
• Experience with standard immunoassays and analysis of analytes in tissues
• Experience with bioanalytical principles and techniques
• Understanding of regulations surrounding bioanalysis
• Ability to direct a large group doing development and analysis
• Ability to identify and address key issues surrounding programs as they encounter new problems/complications
• Ability to thrive in a dynamic, collaborative work environment and communicate effectively both verbally and non-verbally
• Strong organization and multitasking skills, computer and analytical programs (Excel, Word, PowerPoint, Unifi, SoftMax Pro), and familiarity with database management

Preferred Qualifications:

• Experience with assay development in other formats such as hTRF, ECL or Delphia as well as FACS analysis
• Experience with hybridoma generation
• Experience in protein characterization
• List the education and certifications preferred

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.

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Seagen

Seagen is an Equal Opportunity Employer

Submitted: 07/29/2022